The Passerini Reaction is a chemical reaction that involves the formation of α-acylamino acids from isocyanides, aldehydes, and carboxylic acids. This reaction is significant in organic synthesis as it allows for the creation of complex molecules in a straightforward manner. The process typically occurs under mild conditions and can be performed in a one-pot reaction, making it efficient for synthesizing various compounds. In the Passerini Reaction, the isocyanide reacts with an aldehyde to form an intermediate, which then reacts with a carboxylic acid. This reaction is named after the chemist Giovanni Passerini, who first reported it in the 1920s. The versatility of this reaction has made it a valuable tool in the field of medicinal chemistry and drug discovery.