Orofacial syndromes are a group of genetic disorders that affect the development of the face and mouth. These syndromes can lead to various abnormalities, including cleft lip and palate, dental issues, and facial asymmetry. They often result from mutations in specific genes and can be inherited or occur spontaneously. Individuals with orofacial syndromes may experience challenges with eating, speaking, and dental health. Early diagnosis and intervention are crucial for managing symptoms and improving quality of life. Treatment may involve a team of specialists, including dentists, orthodontists, and speech therapists, to address the diverse needs of affected individuals.