Nucleocytoplasmic Large DNA Viruses (NCLDVs) are a diverse group of viruses characterized by their large genomes and complex structures. They primarily infect eukaryotic cells, including those of animals, plants, and fungi. NCLDVs are unique because they replicate in the cytoplasm of the host cell, unlike many other viruses that replicate in the nucleus. These viruses include well-known members such as Poxviruses and Asfarviruses. NCLDVs can have significant ecological and medical implications, as they can influence host cell behavior and contribute to disease. Their large size allows them to encode numerous genes, some of which are involved in processes like DNA repair and immune evasion.