A Norepinephrine Reuptake Inhibitor (NRI) is a type of medication that primarily affects the neurotransmitter norepinephrine in the brain. By blocking the reabsorption of norepinephrine into nerve cells, NRIs increase the levels of this neurotransmitter in the synaptic cleft, which can enhance mood and alleviate symptoms of certain mental health conditions. NRIs are commonly used to treat disorders such as depression and attention deficit hyperactivity disorder (ADHD). They can help improve focus, energy levels, and overall emotional well-being by promoting better communication between nerve cells.