Newcastle Disease is a contagious viral infection that primarily affects birds, especially domestic poultry like chickens and turkeys. It is caused by the Newcastle disease virus, which belongs to the Paramyxoviridae family. The disease can lead to severe respiratory issues, nervous system problems, and high mortality rates in infected flocks. The virus spreads through direct contact with infected birds, contaminated equipment, or through the air. Vaccination is an effective way to prevent Newcastle Disease, and biosecurity measures are essential to control its spread. The disease poses a significant threat to the poultry industry worldwide.