Negative-sense RNA viruses are a type of virus that contain RNA as their genetic material, but their RNA is in a form that cannot be directly translated into proteins. Instead, these viruses must first convert their negative-sense RNA into positive-sense RNA using an enzyme called RNA-dependent RNA polymerase. This positive-sense RNA can then be used to produce viral proteins and replicate the virus. Examples of negative-sense RNA viruses include Influenza virus, Ebola virus, and Rabies virus. These viruses can cause various diseases in humans and animals. Due to their unique replication process, they often require specific treatments and vaccines to manage infections effectively.