NNRTIs, or Non-Nucleoside Reverse Transcriptase Inhibitors, are a class of antiretroviral drugs used to treat HIV infection. They work by binding to the reverse transcriptase enzyme, which is crucial for the replication of the HIV virus. By inhibiting this enzyme, NNRTIs prevent the virus from multiplying in the body. Common NNRTIs include efavirenz, nevirapine, and rilpivirine. These medications are often part of a combination therapy, which helps to improve treatment effectiveness and reduce the risk of drug resistance. NNRTIs are typically taken orally and can have side effects, including rash and liver issues.