Myalgic Encephalomyelitis (ME) is a complex and debilitating condition characterized by extreme fatigue that doesn't improve with rest. It often worsens after physical or mental exertion, a phenomenon known as post-exertional malaise. Other symptoms may include sleep disturbances, cognitive difficulties, and pain in muscles and joints. The exact cause of ME is still not fully understood, but it may involve immune system dysfunction, viral infections, or genetic factors. Diagnosis of ME can be challenging, as there are no specific tests for it. Healthcare providers typically rely on patient history and symptom assessment. Treatment focuses on managing symptoms and improving quality of life, often involving a combination of lifestyle changes, medication, and supportive therapies. Research is ongoing to better understand ME and develop effective treatments.