Missouri-Southern Illinois refers to a geographical region that encompasses parts of both the state of Missouri and Illinois. This area is characterized by its diverse landscapes, including rivers, forests, and rolling hills. The region is known for its rich history, cultural heritage, and various recreational opportunities, such as hiking and fishing. The Missouri River and the Ohio River are significant waterways in this region, contributing to its economy and ecology. Major cities in this area include Cape Girardeau in Missouri and Carbondale in Illinois. The region also features several educational institutions, parks, and historical sites that attract visitors year-round.