The Missisquoi River is a river located in the northeastern United States and southeastern Canada. It flows approximately 50 miles through the state of Vermont and into Quebec, where it eventually joins the Lake Champlain basin. The river is known for its scenic beauty and diverse ecosystems, making it a popular spot for outdoor activities like fishing, kayaking, and birdwatching. The river's watershed supports various wildlife and plant species, contributing to the region's biodiversity. The Missisquoi National Wildlife Refuge is situated along parts of the river, providing habitat for migratory birds and other animals. This area is also significant for its cultural history, with Indigenous peoples having lived along its banks for centuries.