Misfolding diseases, also known as protein misfolding disorders, occur when proteins in the body do not fold into their correct shapes. This improper folding can lead to the formation of toxic aggregates that disrupt normal cellular functions. Common examples include Alzheimer's disease, Parkinson's disease, and Huntington's disease. These diseases can affect various organs and systems, leading to a range of symptoms. The misfolded proteins can accumulate in tissues, causing inflammation and cell death. Research is ongoing to understand the mechanisms behind these diseases and to develop potential treatments that target protein misfolding.