Microbial resistance refers to the ability of microorganisms, such as bacteria, viruses, fungi, and parasites, to withstand the effects of medications that once effectively killed them or inhibited their growth. This resistance can develop through genetic mutations or by acquiring resistance genes from other microbes, making infections harder to treat and leading to longer hospital stays and increased healthcare costs. The rise of microbial resistance is a significant public health concern, as it can result from the overuse and misuse of antibiotics and antiviral medications. Efforts to combat this issue include promoting responsible prescribing practices, improving infection control measures, and investing in research for new treatments and vaccines.