Melrose Plantation is a historic site located in Natchitoches, Louisiana. Established in the late 18th century, it was originally a sugar plantation and later became known for its unique architecture and cultural significance. The plantation features several notable buildings, including the Big House, which showcases a blend of Creole and African influences. Today, Melrose Plantation is recognized for its role in the African American arts and culture, particularly through the work of Clementine Hunter, a renowned folk artist who lived and painted there. The site is listed on the National Register of Historic Places and serves as a museum, offering visitors insight into the region's rich history.