Margherita Colonna was an Italian noblewoman born in the late 13th century. She belonged to the influential Colonna family, which played a significant role in the political and social landscape of medieval Italy. Margherita is often noted for her marriage to Giovanni di Vico, which helped strengthen alliances between powerful families. Throughout her life, Margherita was involved in various political intrigues and conflicts, particularly during the struggles between the Guelphs and Ghibellines. Her family's prominence allowed her to navigate the complexities of noble life, and she is remembered as a key figure in the history of the Colonna lineage.