Manuel Uribe was a Mexican man known for his extreme obesity. Born on June 11, 1965, in Monterrey, Nuevo León, he gained international attention due to his weight, which peaked at around 1,230 pounds (560 kg). His condition was largely attributed to a combination of genetic factors and lifestyle choices. In 2006, Uribe began a weight loss journey that was documented in the media. He adopted a strict diet and exercise regimen, which helped him lose over 400 pounds (180 kg) over several years. Uribe's story raised awareness about obesity and its health implications. He passed away on March 26, 2024.