MKUltra was a covert program initiated by the CIA in the 1950s, aimed at exploring mind control and interrogation techniques. The project involved experiments with various substances, including LSD, and psychological methods to manipulate individuals' behavior and thoughts. The program operated without the consent of many participants, leading to ethical concerns and public outcry. In the 1970s, investigations revealed the extent of the program, resulting in significant changes to regulations regarding human experimentation in the United States.