Lipoatrophy is a medical condition characterized by the loss of fat tissue in specific areas of the body. This can lead to noticeable indentations or a sunken appearance, often affecting the face, arms, and legs. It can occur due to various factors, including certain medications, autoimmune diseases, or viral infections like HIV. In some cases, lipoatrophy is associated with the use of antiretroviral therapy in people living with HIV. The condition can impact a person's self-esteem and quality of life. Treatment options may include cosmetic procedures or switching medications, depending on the underlying cause.