Limbal Stem Cell Deficiency (LSCD) occurs when the stem cells in the limbus, the border between the cornea and the sclera, are damaged or lost. These stem cells are essential for maintaining the health and transparency of the cornea, as they help regenerate the outer layer of the eye. Without them, the cornea can become cloudy, leading to vision problems and discomfort. Common causes of LSCD include chemical burns, trauma, and certain diseases like ocular cicatricial pemphigoid. Symptoms may include redness, pain, and sensitivity to light. Treatment options vary and may involve medications, surgery, or even stem cell transplants to restore corneal health.