The Koyukuk River is a significant waterway in Alaska, flowing approximately 400 miles through the interior of the state. It originates from the Yukon-Tanana Uplands and eventually merges with the Yukon River. The river is known for its scenic beauty and diverse wildlife, making it an important habitat for various species. The Koyukuk region is home to several small communities, including Koyukuk and Nulato. These communities rely on the river for transportation, fishing, and subsistence living. The area is rich in Native Alaskan culture, with traditions that have been passed down for generations, emphasizing the importance of the land and water.