Kearns-Sayre Syndrome (KSS) is a rare genetic disorder that primarily affects the muscles and eyes. It is caused by deletions in mitochondrial DNA, leading to problems with energy production in cells. Common symptoms include progressive weakness of the eye muscles, heart block, and hearing loss. Individuals with KSS may also experience other issues such as diabetes and neurological problems. Diagnosis typically involves genetic testing and clinical evaluation. While there is no cure, management focuses on treating symptoms and improving quality of life through supportive therapies and regular monitoring.