James Hamilton, 1st Lord Hamilton (c. 1430–1479), was a prominent Scottish nobleman during the 15th century. He was the son of James Hamilton, 1st Earl of Arran and played a significant role in the politics of Scotland. He was granted the title of Lord Hamilton in 1445, which established his family's influence in the region. As a supporter of the Stewart dynasty, Hamilton was involved in various conflicts and power struggles of the time. He served as a loyal ally to King James II and was appointed to several important positions, including the role of a governor in the Scottish Highlands. His legacy continued through his descendants, who remained influential in Scottish history.