James Douglas, 6th Earl of Angus (c. 1495–1557) was a Scottish nobleman known for his significant role in the political landscape of 16th-century Scotland. He was a member of the powerful Douglas family, which had a long history of influence in Scottish affairs. His tenure as Earl was marked by shifting alliances and conflicts, particularly during the reign of Mary, Queen of Scots. In 1543, James Douglas was appointed as a guardian to the young Mary, Queen of Scots, reflecting his importance in the royal court. He was involved in various military campaigns and political intrigues, navigating the complexities of Scottish nobility and foreign relations, especially with England. His legacy is intertwined with the turbulent history of Scotland during this period.