Interstate 64 is a major east-west highway in the United States, stretching approximately 2,600 miles. It runs from Virginia Beach, Virginia in the east to St. Louis, Missouri in the west, passing through several states including West Virginia, Kentucky, and Indiana. The highway serves as a vital transportation route, connecting various cities and regions. It facilitates commerce and travel, providing access to important landmarks and attractions along the way, such as Charleston, West Virginia and Louisville, Kentucky.