Integrase is an enzyme that plays a crucial role in the life cycle of certain viruses, particularly retroviruses like HIV. It facilitates the integration of viral DNA into the host cell's genome, allowing the virus to replicate and produce new viral particles. This process is essential for the virus to establish an infection and persist within the host. In addition to its role in viral replication, integrase is a target for antiviral therapies. Drugs that inhibit integrase, known as integrase inhibitors, are used in the treatment of HIV infections. By blocking this enzyme, these medications prevent the virus from integrating its genetic material into the host's DNA, thereby reducing viral load and improving patient outcomes.