Insulin sensitizers are medications that help the body respond better to insulin, a hormone that regulates blood sugar levels. By improving the effectiveness of insulin, these drugs can lower blood sugar levels in people with conditions like type 2 diabetes. Common examples include metformin and thiazolidinediones. These medications work by enhancing the body's sensitivity to insulin, which can lead to improved glucose uptake by cells. This process helps to reduce insulin resistance, a condition where the body's cells do not respond effectively to insulin, often leading to higher blood sugar levels and related health issues.