IL2RG is a gene located on the X chromosome that encodes a protein known as the interleukin-2 receptor gamma chain. This protein plays a crucial role in the immune system by helping various immune cells communicate and respond to infections. It is essential for the function of several interleukin receptors, which are important for immune responses. Mutations in the IL2RG gene can lead to severe combined immunodeficiency (SCID), a condition where the immune system is severely weakened. Individuals with SCID are highly susceptible to infections and require medical interventions, such as bone marrow transplants, to restore immune function.