Hypoxia-Inducible Factor 2 (HIF-2) is a protein that plays a crucial role in how cells respond to low oxygen levels, a condition known as hypoxia. It helps regulate the expression of genes that are involved in processes like red blood cell production, energy metabolism, and blood vessel formation. By activating these genes, HIF-2 helps the body adapt to reduced oxygen availability. HIF-2 is part of a larger family of proteins known as hypoxia-inducible factors, which also includes HIF-1. These proteins are essential for maintaining cellular function and survival in various physiological and pathological conditions, including cancer and cardiovascular diseases. Understanding HIF-2's mechanisms can lead to potential therapeutic strategies for these conditions.