Hypogammaglobulinemia is a medical condition characterized by low levels of immunoglobulins, which are antibodies produced by the immune system. These antibodies play a crucial role in fighting infections. Individuals with hypogammaglobulinemia may experience frequent infections, particularly respiratory and gastrointestinal illnesses, due to their weakened immune response. The condition can be caused by various factors, including genetic disorders, certain medications, or underlying diseases such as multiple myeloma or chronic lymphocytic leukemia. Diagnosis typically involves blood tests to measure immunoglobulin levels, and treatment may include immunoglobulin replacement therapy to help boost the immune system.