The House of Clèves was a noble family in the region of Clèves, located in present-day Germany. It played a significant role in the politics of the Holy Roman Empire during the late Middle Ages and the Renaissance. The family is best known for its connections to the Duchy of Cleves and its influence in the region. One of the most notable figures from the House of Clèves was Anne of Cleves, who became the fourth wife of King Henry VIII of England. Her marriage was politically motivated, but it ended in annulment after just six months. The family's legacy continues to be of interest in European history.