Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) is a genetic disorder that affects the peripheral nerves. It is characterized by a tendency to develop temporary weakness or numbness in the limbs, often triggered by pressure on the nerves, such as from sitting or lying in one position for too long. This condition is caused by mutations in the PMP-22 gene, which plays a crucial role in the formation of myelin, the protective covering of nerves. Individuals with HNPP may experience recurrent episodes of nerve compression, leading to symptoms like tingling, pain, or muscle weakness. These episodes can resolve on their own, but repeated occurrences may lead to long-term nerve damage. Management typically involves avoiding situations that put pressure on the nerves and physical therapy to strengthen affected muscles.