Hayflick Limit
The Hayflick Limit refers to the number of times a normal somatic cell can divide before cell division stops. This phenomenon was discovered by scientist Leonard Hayflick in 1961. Typically, human cells can divide about 40 to 60 times before they enter a state called senescence, where they no longer replicate.
This limit is primarily due to the shortening of telomeres, which are protective caps at the ends of chromosomes. Each time a cell divides, its telomeres become shorter, eventually leading to cell aging and death. The Hayflick Limit is significant in understanding aging and the development of age-related diseases.