Hantavirus Pulmonary Syndrome (HPS) is a severe respiratory disease caused by the Hantavirus, which is primarily transmitted to humans through contact with infected rodents or their droppings. Symptoms typically begin with fever, muscle aches, and fatigue, followed by difficulty breathing as the disease progresses. Early diagnosis and supportive care are crucial, as HPS can lead to serious complications and can be fatal. Preventive measures include avoiding contact with rodents and maintaining clean living environments to reduce the risk of exposure to the virus.