HSD17B2 is a gene that encodes an enzyme called 17β-hydroxysteroid dehydrogenase type 2. This enzyme plays a crucial role in the metabolism of steroid hormones, particularly in converting testosterone and estradiol into their less active forms. This process is important for regulating hormone levels in the body. The activity of HSD17B2 is significant in various tissues, including the liver and reproductive organs. Abnormalities in this gene can lead to hormonal imbalances, which may contribute to conditions such as infertility or endometriosis. Understanding HSD17B2 is essential for research in reproductive health and endocrine disorders.