HLA-B*5701
HLA-B*5701 is a specific variant of the human leukocyte antigen (HLA) gene, which plays a crucial role in the immune system. This gene helps the body recognize and respond to foreign substances, such as viruses and bacteria. The presence of HLA-B*5701 is particularly important in the context of HIV treatment, as it is associated with a hypersensitivity reaction to the medication abacavir.
Individuals who carry the HLA-B*5701 allele are at a higher risk of developing severe allergic reactions when taking abacavir. Therefore, genetic testing for HLA-B*5701 is recommended before starting treatment with this drug. Identifying this allele helps healthcare providers ensure patient safety and select appropriate medications.