The Guise family was a prominent noble family in France during the Renaissance and early modern periods. They were known for their significant political influence and their role in the French Wars of Religion. The family produced several important figures, including Henry I, Duke of Guise, who was a key leader of the Catholic League. The Guise family was often associated with the Valois dynasty and had strong ties to the French monarchy. Their rivalry with the Bourbon family contributed to the complex power struggles of the time. The family's legacy is marked by their ambition and involvement in the tumultuous politics of 16th-century France.