Granulomatosis is a condition characterized by the formation of small clusters of immune cells called granulomas. These granulomas can develop in various tissues and organs, often as a response to inflammation or infection. The presence of granulomas can disrupt normal tissue function and may lead to symptoms depending on the affected area. One common type of granulomatosis is Wegener's granulomatosis, now known as granulomatosis with polyangiitis. This autoimmune disease primarily affects the respiratory system and kidneys. Diagnosis typically involves imaging studies, blood tests, and sometimes a biopsy to confirm the presence of granulomas. Treatment often includes medications to reduce inflammation and suppress the immune response.