Gomori's Trichrome is a histological staining technique used to differentiate between various types of tissues in microscopic samples. It highlights collagen fibers in blue or green, while muscle fibers and cytoplasm appear red. This contrast helps pathologists identify connective tissue disorders and assess tissue architecture. The staining process involves several steps, including fixation, dehydration, and application of specific dyes. Gomori's Trichrome is particularly useful in studying liver, kidney, and lung tissues, as it allows for the visualization of fibrosis and other pathological changes. This technique is essential in both research and clinical diagnostics.