Genomic variants are differences in the DNA sequence among individuals. These variations can occur in a single nucleotide, known as a single nucleotide polymorphism (SNP), or involve larger segments of DNA, such as insertions, deletions, or duplications. Genomic variants can influence traits, disease susceptibility, and responses to medications. Some genomic variants are benign, while others can lead to genetic disorders. For example, certain variants are associated with conditions like cystic fibrosis or sickle cell disease. Understanding these variants is crucial for advancements in personalized medicine and genetic research, helping to tailor treatments based on an individual's unique genetic makeup.