GJB6 is a gene that provides instructions for making a protein called gap junction beta-6. This protein is part of a larger family known as gap junction proteins, which help form channels between cells. These channels allow for the direct transfer of small molecules and ions, facilitating communication between neighboring cells. Mutations in the GJB6 gene can lead to various health issues, particularly affecting hearing. One common condition associated with GJB6 mutations is nonsyndromic hearing loss, which is characterized by hearing impairment that is not linked to other symptoms or syndromes.