Friedel-Crafts acylation
Friedel-Crafts acylation is an important organic reaction that introduces an acyl group into an aromatic compound. This process typically involves the reaction of an aromatic ring with an acyl chloride or an anhydride in the presence of a catalyst, usually aluminum chloride. The acyl group replaces a hydrogen atom on the aromatic ring, resulting in a ketone derivative.
This reaction is valuable in organic synthesis because it allows for the formation of more complex molecules. The resulting acylated aromatic compounds can be further modified, making Friedel-Crafts acylation a key step in the production of various pharmaceuticals and fine chemicals.