Fibrillin-1 is a crucial protein that plays a significant role in the formation of elastic fibers in connective tissues. It is essential for maintaining the structural integrity of various tissues, including skin, blood vessels, and lungs. Mutations in the gene that encodes Fibrillin-1 can lead to disorders such as Marfan Syndrome, which affects the body's connective tissue and can result in serious cardiovascular issues. This protein is primarily found in the extracellular matrix, where it helps to provide elasticity and strength to tissues. Fibrillin-1 also interacts with other proteins, contributing to the overall function and stability of the connective tissue framework. Understanding Fibrillin-1 is vital for research into genetic disorders and tissue engineering.