The Fall of Rome refers to the decline and eventual collapse of the Roman Empire in the 5th century AD. This process was gradual, influenced by various factors such as economic troubles, military defeats, and political instability. The empire faced invasions from various tribes, including the Visigoths and Vandals, which weakened its borders and resources. In 476 AD, the last Roman emperor, Romulus Augustulus, was overthrown by the Germanic leader Odoacer, marking a significant point in the empire's fall. This event is often considered the end of ancient Rome and the beginning of the Middle Ages in Europe.