Expedition 49 was a mission to the International Space Station (ISS) that took place from September 2016 to February 2017. The crew included astronauts from NASA, Roscosmos, and ESA, who worked together to conduct scientific research and perform maintenance on the station. During this expedition, the crew carried out various experiments in fields such as biology, physics, and earth science. They also participated in spacewalks to upgrade the ISS's systems and ensure its continued operation, contributing to the ongoing exploration of space and the advancement of human knowledge.