Dystrophic Epidermolysis Bullosa (DEB) is a rare genetic skin disorder characterized by fragile skin that blisters easily. It results from mutations in the COL7A1 gene, which is essential for producing type VII collagen, a protein that helps anchor the skin's layers together. People with DEB often experience painful blisters and wounds, particularly in areas subjected to friction or trauma. The severity of DEB can vary widely, with some individuals facing mild symptoms while others may have severe complications, including scarring and increased risk of skin infections. Management typically involves wound care and pain relief, and in some cases, surgical interventions may be necessary to address complications.