The title "Duke of Milan" refers to a noble rank historically associated with the city of Milan in northern Italy. The position was established in the late Middle Ages and became prominent during the Renaissance. The Duke held significant political and military power, often ruling over the surrounding territories and engaging in conflicts with rival states. Notable figures who held the title include Ludovico Sforza, a key patron of artists like Leonardo da Vinci and Michelangelo. The duchy was influential in shaping the cultural and political landscape of Italy during its time, contributing to the development of art, architecture, and governance in the region.