Duke Paul Frederick of Mecklenburg (born 1890, died 1945) was a member of the House of Mecklenburg. He was the son of Duke Paul Friedrich of Mecklenburg and Princess Maria of Schleswig-Holstein. Paul Frederick held the title of Duke and was known for his involvement in the cultural and political life of his region. During his lifetime, he faced significant challenges due to the political changes in Germany and the impact of World War II. After the war, he was captured by Soviet forces and died in captivity. His legacy is tied to the history of the Mecklenburg region and its noble families.