Duke Henry V of Mecklenburg (c. 1383–1422) was a notable nobleman from the House of Mecklenburg, a prominent dynasty in northern Germany. He ruled the duchy of Mecklenburg alongside his brother, Duke John IV, and was known for his efforts to strengthen the region's political and economic stability during the late medieval period. Henry V played a significant role in the Hanseatic League, a powerful trading alliance in northern Europe. His leadership contributed to the development of trade and commerce in Mecklenburg, helping to enhance the duchy's influence in the region.