Duke Henry VI of Mecklenburg (c. 1470–1525) was a notable nobleman from the Mecklenburg region in northern Germany. He belonged to the House of Mecklenburg and played a significant role in the political landscape of his time. His reign was marked by efforts to strengthen the duchy and maintain its independence amid the shifting alliances of the Holy Roman Empire. Henry VI was also known for his patronage of the arts and support of education. He contributed to the development of Rostock University, one of the oldest universities in Germany. His leadership helped shape the cultural and political identity of the Mecklenburg region during the late medieval period.