Dorothea of Brandenburg (1430–1495) was a German noblewoman and the daughter of Elector Frederick I of Brandenburg. She became the Duchess of Saxony through her marriage to Duke Ernest of Saxony in 1445. Dorothea played a significant role in the political landscape of her time, supporting her husband's rule and managing the ducal court. As a member of the House of Hohenzollern, Dorothea's lineage connected her to influential families in Europe. She was known for her piety and charitable works, contributing to the welfare of her community and the church. Her legacy includes the promotion of education and the arts in her duchy.