Differentiation of Self is a psychological concept that refers to an individual's ability to maintain their sense of self while being emotionally connected to others. This balance allows a person to think and act independently, even in close relationships, reducing anxiety and promoting healthy interactions. It is a key idea in the work of Murray Bowen, a psychiatrist who developed family systems theory. Individuals with high differentiation can express their thoughts and feelings without being overly influenced by others' opinions. They can manage their emotions effectively, leading to better decision-making and stronger relationships. This concept is essential for personal growth and emotional well-being.